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Chemical Structure : CP-346086
Catalog No.: PC-60675Not For Human Use, Lab Use Only.
A potent, orally active microsomal triglyceride transfer protein (MTP) inhibitor that inhibits both human and rodent MTP with IC50 of 2 nM.
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A potent, orally active microsomal triglyceride transfer protein (MTP) inhibitor that inhibits both human and rodent MTP with IC50 of 2 nM; inhibits apolipoprotein B (apoB) and triglyceride secretion (IC50=2.6 nM) without affecting apoA-I secretion or lipid synthesis; lowers total, VLDL, and LDL cholesterol and triglycerides in rats.
| M.Wt | 477.491 | |
| Formula | C26H22F3N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chandler CE, et al. J Lipid Res. 2003 Oct;44(10):1887-901.
2. Lamant M, et al. J Biol Chem. 2006 Nov 24;281(47):36289-302.
3. Kim E, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):775-85.
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