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Chemical Structure : CP5V
CAS No.: 2509359-75-3
Catalog No.: PC-20565Not For Human Use, Lab Use Only.
CP5V (apcin-A-PEG5-VHL Ligand 1) is an efficient, selective Cdc20 PROTAC with DC50 of 1.6 uM in both MCF7 and MDA-MB-231 cells, induces mitotic inhibition and suppresses cancer cell proliferation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $458 | In stock | |
| 5 mg | $988 | In stock | |
| 10 mg | $1580 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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CP5V (apcin-A-PEG5-VHL Ligand 1) is an efficient, selective Cdc20 PROTAC with DC50 of 1.6 uM in both MCF7 and MDA-MB-231 cells, induces mitotic inhibition and suppresses cancer cell proliferation.
CP5V-induced degradation of Cdc20 is mediated through the ubiquitin-proteasome pathway.
CP5V-induced Cdc20 degradation is sensitive to neddylation inhibitor MLN4924.
CP5V efficiently binds onto Cdc20 (SOR KD=11.2 uM) to help stabilize Cdc20-PROTACS-VHL-ElonginC-ElonginB complex.
CP5V significantly inhibits mitotic progression and induces breast cancer cell death.
CP5V restores Taxol-induced cytotoxic response in Taxol-resistant cells.
CP5V is a potent inhibitor that suppresses breast tumor progression with no toxicity in 4T1 xenograft model.
| M.Wt | 1075.49 | |
| Formula | C46H66Cl3N9O12S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
ClC(Cl)(Cl)C(NC(OCCCNC(CCOCCOCCOCCOCCOCCC(N[C@@H](C(C)(C)C)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O)=O)=O)NC4=NC=CC=N4 |
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1. Junlong Jack Chi, et al. EBioMedicine. 2019 Nov;49:40-54.
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