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Chemical Structure : CPI-360
CAS No.: 1802175-06-9
Catalog No.: PC-21930Not For Human Use, Lab Use Only.
CPI-360 is a potent, selective EZH2 inhibitor with IC50 of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CPI-360 is a potent, selective EZH2 inhibitor with IC50 of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2, respectively.
CPI-360 decreases cellular levels of H3K27me3 and H3K27me2 (EC50, 56 and 65 nM, respectively), triggering cell cycle arrest and ultimately resulting in apoptosis in a large panel of non-Hodgkin's lymphoma (NHL) cell lines.
CPI-360 (200 mg/kg) reduced tumor growth of KARPAS-422 xenografts in mice.
| M.Wt | 437.54 | |
| Formula | C25H31N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[(1,2-Dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-2-methyl-1-[(1R)-1-(tetrahydro-2H-pyran-4-yl)ethyl]-1H-indole-3-carboxamide |
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1. Gehling VS, et al. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3644-9.
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