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Chemical Structure : CPI-637
CAS No.: 1884712-47-3
Catalog No.: PC-42168Not For Human Use, Lab Use Only.
A potent and selective, cell-active CBP/EP300 bromodomain inhibitor with CBP BRET EC50 of 0.03 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | Get quote |
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CPI-637 is a potent and selective, cell-active CBP/EP300 bromodomain inhibitor with CBP BRET EC50 of 0.03 uM.
CPI-637 displays >700-fold selectivity over the BET bromodomains (BRD4 IC50=11.0 uM).
CPI-637 is also highly selective against other bromodomains.
CPI-637 inhibits the expression of MYC with an EC50 of 0.60 uM in a cellular assay.
| M.Wt | 386.4497 | |
| Formula | C22H22N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO |
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| Chemical Name/SMILES |
2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-, (4R)- |
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1. Taylor AM, et al. ACS Med Chem Lett. 2016 Mar 15;7(5):531-6.
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