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Chemical Structure : CPI703
Catalog No.: PC-60856Not For Human Use, Lab Use Only.
CPI-703 (CPI703) potent, selective, cell-active CBP/EP300 bromodomain inhibitor with IC50 of 0.47 uM for CBP.
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CPI-703 (CPI703) potent, selective, cell-active CBP/EP300 bromodomain inhibitor with IC50 of 0.47 uM for CBP.
CPI-703 displays little to no (>200-fold selectivity) activity for BRD9, BRD4, BRPF1, TRIM24, BRG1 and BACF (IC50>10 uM).
CPI-703 inhibits CBP bromodomain binding in a dose-dependent manner with cellular EC50 of 2.1 uM, reduces Treg differentiation and exhibits FOXP3 inhibition with IC50 of 1.5 uM.
CPI-703 significantly affects TH17 differentiation, suppresses TH17 cytokines, IL-17A, IL-17F, and IL-21 with no effect on TNFα production or cell viability.
| M.Wt | 298.39 | |
| Formula | C17H22N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ghosh S, et al. J Biol Chem. 2016 Jun 17;291(25):13014-27.
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