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CPK20

Chemical Structure : CPK20

CAS No.: 2397708-22-2

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CPK20 (KCNT1 channel inhibitor CPK20)

Catalog No.: PC-22388Not For Human Use, Lab Use Only.

CPK20 is a potent, selective inhibitor / blocker of potassium (K+) channel KCNT1 (KNa1.1, Slo2.2, SLACK) with IC50 of 6.4 uM in fluorescence-based assay FluxOR.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CPK20 is a potent, selective inhibitor / blocker of potassium (K+) channel KCNT1 (KNa1.1, Slo2.2, SLACK) with IC50 of 6.4 uM in fluorescence-based assay FluxOR.
CPK20 (10 uM) blocked KCNT1 currents almost completely.
CPK20 is devoid of hERG-blocking activity.
CPK20 could block preferentially KCNT1 vs KCNT2 channels, and to exert a potent blocking effect over clinically-relevant pathogenic KCNT1 variants, thus revealing its potential as target therapy for patients affected by KCNT1-related epilepsies.

Physicochemical Properties

M.Wt 506.51
Formula C23H24F6N2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-{1-[2,4-Bis(trifluoromethyl)benzyl]indolin-5-yl}cyclohexanesulfonamide

References

1. Nunzio Iraci, et al. Journal of Medicinal Chemistry, May 23, 2024.

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