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Chemical Structure : CPR1-B
Catalog No.: PC-49730Not For Human Use, Lab Use Only.
CPR1-B is a longer-acting phenylhexanamide mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.3 nM (Emax=89%).
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CPR1-B is a longer-acting phenylhexanamide mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.3 nM (Emax=89%).
CPR1-B promotes the relaxed/active MFN2 conformation without affecting catalytic GTPase activity.
CPR1-B is a longer acting compound that can provide sustained mitofusin activation.
CPR1-B (60 mg/kg given orally twice daily) causes sustained mitofusin activation in 50-week-old MFN2 T105M mice.
CPR1-B modified phenotypes in vitro and in vivo in murine amyotrophic lateral sclerosis (ALS).
CPR1-B exhibits sustained brain levels, markedly prolonged pharmacodynamic effects, and disease modification in a proof-of-concept study of murine amyotrophic lateral sclerosis.
| M.Wt | 301.43 | |
| Formula | C19H27NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dang X, et al. J Med Chem 64:12506–12524.
2. Franco A, et al. J Pharmacol Exp Ther. 2022 Nov;383(2):137-148.
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