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Chemical Structure : CRT-0105950
CAS No.: 1661845-86-8
Catalog No.: PC-70101Not For Human Use, Lab Use Only.
CRT-0105950 (CRT0105950) is a novel potent LIMK inhibitor with IC50 of 0.3 nM and 1 nM for LIMK1 and LIMK2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $258 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CRT-0105950 (CRT0105950) is a novel potent LIMK inhibitor with IC50 of 0.3 nM and 1 nM for LIMK1 and LIMK2, respectively.
CRT-0105950 inhibits cofilin phosphorylation and increase αTubulin acetylation in cells.
CRT-0105950 shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=19.2 uM).
| M.Wt | 393.889 | |
| Formula | C21H16ClN3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-((5-(3-(2-chloro-4-methylphenyl)pyridin-4-yl)thiazol-2-yl)amino)phenol |
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1. Mardilovich K, et al. Oncotarget. 2015 Nov 17;6(36):38469-86.
2. Charles MD, et al. J Med Chem. 2015 Oct 22;58(20):8309-13.
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