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CS640

Chemical Structure : CS640

CAS No.: 2388506-83-8

CS640 (CS-640)

Catalog No.: PC-72909Not For Human Use, Lab Use Only.

CS640 (CS-640) is a potent, selective CaMK1D inhibitor with nanomolar range at both the enzymatic and cellular levels.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CS640 (CS-640) is a potent, selective CaMK1D inhibitor with nanomolar range at both the enzymatic and cellular levels.
CS640 prevent Aβ induced tau hyperphosphorylation in culture, but were not able to protect cells from Aβ induced toxicity.
CS640 was able to ablate Aβ induced increased tau phosphorylation at Thr181 in mouse primary neurons.

Physicochemical Properties

M.Wt 397.527
Formula C21H31N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-[(3S)-3-Amino-1-piperidinyl]-4-[[2,6-bis(1-methylethyl)-4-pyridinyl]amino]-5-pyrimidinecarboxamide

References

1. Paige Grant, et al. Molecules. 2021 Dec 18;26(24):7669.

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