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Cat. No. Product Name CAS No. Information
PC-43468

KN-62

127191-97-3 KN-62 is a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMK II) with Ki of 900 nM for rat brain CaMK II; potently antagonizes ATP-stimulated Ba2+ influx into fura-2 loaded human lymphocytes with IC50 of 12.7 nM, inhibits ATP-stimulated ethidium+ uptake with IC50 of 13.1 nM; causes hypertension and tachycardia in rats, associated with the diminished rate of GABA release in cerebrospinal fluid.
PC-63352

CAMKK2 inhibitor 4t

CAMKK2 inhibitor 4t is a potent, selective, orally available, brain-penetrant CAMKK2 inhibitor with pIC50 of 8.5; potently inhibits AMPK phosphorylation in a hypothalamus-derived cell line with pIC50 of 6.3; reduces food intake in rodent models.
PC-45723

STO-609

52029-86-4 STO-609 is a selective and cell-permeable inhibitor of CaM-KK; inhibits recombinant CaM-KKα and CaM-KKβ with Ki of 80 and 15 ng/ml; without any significant effect on the downstream CaM kinases (CaM-KI and -IV, IC50 >10 ug); suppresses the Ca(2+)-induced activation of CaM-KIV in a dose-dependent manner in transfected HeLa cells; significantly reduces the endogenous activity of CaM-KK in SH-SY5Y neuroblastoma cells (1 ug/ml, 80% inhibition).
PC-45443

CaMKII-IN-1

1208123-85-6 A potent and highly selective CaMKII inhibitor with IC50 of 63 nM; no inhibitory effect for CaMKIV, MLCK, p38α, Akt1, PKC etc; shows 25-fold higher potency than KN-93.

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