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Chemical Structure : CT-179
Catalog No.: PC-38755Not For Human Use, Lab Use Only.
CT-179 is a small molecule inhibitor of protein transcription factor OLIG2 (Oligodendrocyte transcription factor 2), CT-179 is a putative disruptor of OLIG2 homodimerization.
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CT-179 is a small molecule inhibitor of protein transcription factor OLIG2 (Oligodendrocyte transcription factor 2), CT-179 is a putative disruptor of OLIG2 homodimerization.
CT-179 profoundly inhibited the growth of, and induced apoptosis in, a range of patient-derived HGG cell lines at low nanomolar concentrations.
CT-179 caused significant downregulation of receptor tyrosine kinases that are associated with HGG tumorigenicity, including EGFR and PDGFR. Orally administered CT-179 (20 mg/kg) crossed the blood-brain barrier of intact mice and reached levels sufficient to inhibit HGG cells.
CT-179 inhibited cell viability of pediatric glioblastoma (pGBM) cells in vitro, and effectively penetrated and accumulated in CNS tissues and PDOX tumors.
| M.Wt | 397.304 | |
| Formula | C17H22Cl2N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xu Z, et al. Clin Cancer Res. 2022 May 26:clincanres.0527.2022-3-18 13:13:01.167.
2. Holly Lindsay, et al. Cancer Res (2019) 79 (13_Supplement): LB-320.
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