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Chemical Structure : CTIBD
Catalog No.: PC-72121Not For Human Use, Lab Use Only.
CTIBD is a novel potent activator of the BKCa channel with EC50 of 3.9 uM.
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CTIBD is a novel potent activator of the BKCa channel with EC50 of 3.9 uM.
CTIBD showed significantly higher potency compared with three other known BKCa activators: NS 1619, NS 11021, and rottlerin.
CTIBD induced a reversible potentiation of macroscopic outward currents of the BKCa channel, CTIBD activates both rSlo/rβ1 and rSlo/rβ4 coexpressed channels mainly by decreasing the closing rate of the channel.
CTIBD concentration-dependently reduced ACh-induced contractions in isolated rat urinary bladder strips.
CTIBD effectively restored frequent voiding contraction and lowered voiding volume without affecting other bladder function parameters in acetic acid-induced overactive bladder (OAB) model (i.p. 20 mg/kg).
| M.Wt | 355.697 | |
| Formula | C16H9ClF3NO3 | |
| Appearance | Solid | |
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1. Narasaem Lee, et al. Mol Pharmacol. 2021 Feb;99(2):114-124.
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