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Chemical Structure : CTPS-IN-T35
CAS No.: 2338811-71-3
Catalog No.: PC-72551Not For Human Use, Lab Use Only.
CTPS-IN-T35 is a potent, small molecule inhibitor of CTPS (cytidine triphosphate synthase) with IC50 of 4.7/25.7 nM against CTPS1/2 in RapdFire MS assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $318 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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CTPS-IN-T35 is a potent, small molecule inhibitor of CTPS (cytidine triphosphate synthase) with IC50 of 4.7/25.7 nM against CTPS1/2 in RapdFire MS assays.
CTPS-IN-T35 inhibited lymphocyte proliferation (Jurkat cells IC50=6 nM, human/mouse T-Cells IC50=24/63.5 nM) by preventing expansion of CTP pools via de novo synthesis.
| M.Wt | 512.526 | |
| Formula | C20H19F3N6O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(2-(cyclopropanesulfonamido)thiazol-4-yl)-2-methyl-N-(5-(6-(trifluoromethyl)pyrazin-2-yl)pyridin-2-yl)propanamide |
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1. Eric M Lynch, et al. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2107968118.
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