Catalog No.: PC-62178Not For Human Use, Lab Use Only.
CUR61414 is a small molecule Hedgehog (Hh) inhibitor that can block elevated Hh signaling activity resulting from oncogenic mutations in Patched-1, binds directly with Smoothened (Ki=44 nM).
CUR61414 is a small molecule Hedgehog (Hh) inhibitor that can block elevated Hh signaling activity resulting from oncogenic mutations in Patched-1, binds directly with Smoothened (Ki=44 nM).
CUR61414 inhibits Hh-induced cellular activity (IC50=100-200 nM).
CUR61414 suppresses proliferation and induces apoptosis of basaloid nests in the BCC model systems, whereas having no effect on normal skin cells.
