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Chemical Structure : CXL017
Catalog No.: PC-62866Not For Human Use, Lab Use Only.
CXL017 is a small molecule that has selective cytotoxicity toward MDR cancer cell lines in vitro, through inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) with IC50 of 15 uM.
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CXL017 is a small molecule that has selective cytotoxicity toward MDR cancer cell lines in vitro, through inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) with IC50 of 15 uM.
CXL017 selectively suppresses the growth of tumors derived from the MDR cancer cell line, HL60/MX2, in vivo.
CXL017 significantly downregulates Mcl-1 and Bax and up-regulates Noxa, Bim, Bcl-XL, SERCA2, and SERCA3 proteins, along with a reduction in endoplasmic reticulum (ER) calcium content in HL60/MX2 cells.
CXL017 elicits its cytotoxic effect, in part, through inhibition of the SERCA.
| M.Wt | 441.48 | |
| Formula | C24H27NO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Das SG, et al. ACS Chem Biol. 2013 Feb 15;8(2):327-35.
2. Aridoss G, et al. J Med Chem. 2012 Jun 14;55(11):5566-81.
3. Hermanson DL, et al. Mol Pharmacol. 2013 Aug;84(2):236-43.
4. Bleeker NP, et al. Mol Pharm. 2013 Nov 4;10(11):4358-66.
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