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CXT29

Chemical Structure : CXT29

CAS No.: 3132301-54-0

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CXT29 (CXT-29)

Catalog No.: PC-28609Not For Human Use, Lab Use Only.

CXT29 is a potent, dual inhibitor of cyclooxygenase (COX) and thromboxane receptor (TP receptor) antagonist with IC50 of 13 nM/772 nM for COX-2/COX-1, inhibits platelet aggregation with IC50 of 96 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CXT29 is a potent, dual inhibitor of cyclooxygenase (COX) and thromboxane receptor (TP receptor) antagonist with IC50 of 13 nM/772 nM for COX-2/COX-1, inhibits platelet aggregation with IC50 of 96 nM.
CXT29 suppresses TXA2-dependent platelet aggregation and inflammatory pain in mice after oral administration at 50 mg/kg.

Physicochemical Properties

M.Wt 367.42
Formula C22H22FNO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(8-benzyl-1-ethyl-6-fluoro-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid

References

1. Blua F, et al. J Med Chem. 2025 Nov 13;68(21):23185-23219.

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