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Cat. No. Product Name CAS No. Information
PC-60430

ASP-6537

524699-72-7

ASP-6537 (ASP6537) is a novel potent, selective, reversible cyclooxygenase-1 (COX-1) inhibitor with IC50 of 4.9 nM; displays 650-fold selectivity over COX-2 (IC50=3.2 uM); dose dependently inhibits carrageenan-induced paw edema (ED30=22 mg/kg) and paw swelling associated with adjuvant arthritis (ED50=17 mg/kg) in rats; also inhibits TXA2 production more selectively than aspirin in in vitro and in vivo, exerts potent antithrombotic effect in rats.

PC-45989

(S)-( )-Ibuprofen

51146-56-6

An enantiomer of Ibuprofen that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form; also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC50=62 and 122 uM, respectively).

PC-42668

Flurbiprofen

5104-49-4

A non-steroidal anti-inflammatory drug (NSAID); primarily indicated as a pre-operative anti-miotic as well as orally for arthritis or dental pain; cyclooxygenase (COX) inhibitor.

Pain

Approved

PC-42511

(R)-Flurbiprofen

51543-40-9

A non-steroidal anti-inflammatory drug (NSAID); primarily indicated as a pre-operative anti-miotic as well as orally for arthritis or dental pain; cyclooxygenase (COX) inhibitor.

Pain

Approved

PC-63183

Robenacoxib

220991-32-2 Robenacoxib is a nonsteroidal anti-inflammatory drug (NSAID) used in veterinary medicine for the relief of pain and inflammation in cats and dogs, a Cyclooxygenase(COX)-1 and COX-2 inhibitor.
PC-63065

Polmacoxib

301692-76-2 Polmacoxib (CG-100649) is a novel NSAID proposed to inhibit both COX-2 and carbonic anhydrase (CA)-I/-II; inhibits premalignant and malignant colorectal lesions in mouse models, partly through inhibiting tumor cell proliferation; induces the G2/M cell cycle arrest in colon cancer cells, and inhibits the tumor growth in colon cancer xenograft in nude mice.

Rheumatoid Arthritis

Approved

PC-62969

NCX-4016

175033-36-0 NCX-4016 (Nitroaspirin;NO-Aspirin 1) is a nitroderivative of aspirin that combines cyclooxygenase inhibitor with an NO donor, directly and irreversiblely inhibits COX-1; suppresses platelet activation, platelet aggregation and thromboxane A2 production, reduces infarct size caused by myocardial ischemia-reperfusion in the anesthetized rat.

Diabetes

Phase 2 Discontinued

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