Catalog No.: PC-26389Not For Human Use, Lab Use Only.
CZ-48 (Sulfo-ara-F-NMN) is a mimetic of nicotinamide mononucleotide (NMN) and selective cell-permeant activator of SARM1, activate SARM1 to produce cADPR from NAD, does not inhibit CD38.
CZ-48 (Sulfo-ara-F-NMN) is a mimetic of nicotinamide mononucleotide (NMN) and selective cell-permeant activator of SARM1, activate SARM1 to produce cADPR from NAD, does not inhibit CD38.
CZ-48 induced increase in the cADPR levels in SARM1-expressing cells.
CZ-48 activates SARM1 via a conformational change of the auto-inhibitory domain and dimerization of its catalytic domain.
CZ-48 mimics cellular NMN in activating SARM1 enzymatically.
CZ-48 elevates cADPR, depletes NAD and ATP, and induces non-apoptotic death in SARM1-overexpressing cells.
