CZL-105 | p300/CBP inhibitor | Probechem Biochemicals

Chemical Structure : CZL-105

CZL-105 (CZL105)

Catalog No.: PC-27353Not For Human Use, Lab Use Only.

CZL-105 is a potent, selective and orally active p300/CBP bromodomain inhibitor, while sparing BET and demonstrates strong antiproliferative potency in OPM-2 multiple myeloma cells.

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Biological Activity

CZL-105 is a potent, selective and orally active p300/CBP bromodomain inhibitor, while sparing BET and demonstrates strong antiproliferative potency in OPM-2 multiple myeloma cells.

Physicochemical Properties

M.Wt	561.66
Formula	C31H36FN5O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Piperidinone, 6-[7-(3,5-dimethyl-4-isoxazolyl)-3-[(trans-4-methoxycyclohexyl)amino]imidazo[1,2-a]pyridin-2-yl]-1-(3-fluoro-4-methoxyphenyl)-, (6S)-

References

1. Zonglong Chen, et al. J Med Chem. 2026 Jul 17. doi: 10.1021/acs.jmedchem.5c03730.

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CZL-105 (CZL105)

Biological Activity

Physicochemical Properties

References

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