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CaMK1D-IN-18

Chemical Structure : CaMK1D-IN-18

CAS No.: 2692620-19-0

CaMK1D-IN-18

Catalog No.: PC-72908Not For Human Use, Lab Use Only.

CaMK1D-IN-18 is a potent, selective CaMK1D inhibitor with IC50 of 31 nM, >150-fold greater activity against CaMK1D than all non-CaMK1 kinases.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CaMK1D-IN-18 is a potent, selective CaMK1D inhibitor with IC50 of 31 nM, >150-fold greater activity against CaMK1D than all non-CaMK1 kinases.
CaMK1D-IN-18 improves insulin sensitivity and glucose control in the diet-induced obesity mouse model after both acute and chronic administration.

Physicochemical Properties

M.Wt 483.017
Formula C24H31ClN8O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-2-(3-Aminopiperidin-1-yl)-4-((3,5-bis(2-cyanopropan-2-yl)phenyl)amino)pyrimidine-5-carboxamide Hydrochloride

References

1. Christophe Fromont, et al. J Med Chem. 2020 Jul 9;63(13):6784-6801.

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