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Candesartan

Chemical Structure : Candesartan

CAS No.: 139481-59-7

Candesartan (CV 11974, CV11974, CV-11974)

Catalog No.: PC-70201Not For Human Use, Lab Use Only.

Candesartan (CV-11974) is a potent, selective angiotensin II receptor antagonist, inhibits the binding of [125I] angiotensin II to the bovine adrenal cortical membrane and rabbit aortic membrane with IC50 of 112 nM and 28.6 nM, has potent and long-lasting antihypertensive effects.

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Biological Activity

Candesartan (CV-11974) is a potent, selective angiotensin II receptor antagonist, inhibits the binding of [125I] angiotensin II to the bovine adrenal cortical membrane and rabbit aortic membrane with IC50 of 112 nM and 28.6 nM, has potent and long-lasting antihypertensive effects.

Physicochemical Properties

M.Wt 440.45
Formula C24H20N6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-7-benzimidazolecarboxylic acid

References

1. Shibouta Y, et al. J Pharmacol Exp Ther. 1993 Jul;266(1):114-20.

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