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Chemical Structure : Carmofur
CAS No.: 61422-45-5
Catalog No.: PC-47071Not For Human Use, Lab Use Only.
Carmofur (HCFU) is a pyrimidine analogue with antineoplastic activity, Carmofur is a highly potent acid ceramidase (ASAH1) inhibitor with IC50 of 29 nM (rat recombinant ASAH1).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $158 | In stock | |
| 100 mg | $298 | In stock | |
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Carmofur (HCFU) is a pyrimidine analogue with antineoplastic activity, Carmofur is a highly potent acid ceramidase (ASAH1) inhibitor with IC50 of 29 nM (rat recombinant ASAH1).
Carmofur inhibits acid ceramidase (ASAH1) activity and elevates tissue ceramide levels, both in vitro and in vivo.
Carmofur act synergistically with standard antitumoral drugs to prevent cancer cell proliferation.
Carmofur is highly effective and specifically target glioblastoma GSCs.
| M.Wt | 257.26 | |
| Formula | C11H16FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide |
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1. Doan NB, et al. Oncol Rep. 2017 Oct;38(4):1932-1940.
2. Natalia Realini, et al. Sci Rep. 2013;3:1035. doi: 10.1038/srep01035.
3. Doan NB, et al. Oncotarget. 2017 Nov 7;8(68):112662-112674.
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