Cbl-b inhibitor 3 | Cbl-b inhibitor | Probechem Biochemicals

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Chemical Structure : Cbl-b inhibitor 3

Catalog No.: PC-21634Not For Human Use, Lab Use Only.

Cbl-b inhibitor 3 is a potent, selective inhibitor of RING finger E3 ligase Cbl-b with IC50 of 5.5 nM in Cbl-b LCK Ub TR-FRET assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Cbl-b inhibitor 3 is a potent, selective inhibitor of RING finger E3 ligase Cbl-b with IC50 of 5.5 nM in Cbl-b LCK Ub TR-FRET assays.

M.Wt	667.78
Formula	C35H44F3N7O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(6-(cyclopentyloxy)-4-(3-((4-methyl-4H-1,2,4-triazol-3-yl)methyl)oxetan-3-yl)pyridin-2-yl)-6-((2-isopropyl-4-methylpiperazin-1-yl)methyl)-4-(trifluoromethyl)isoindolin-1-one

1. Patent WO2022169997 A1.

2. Sabnis RW. ACS Med Chem Lett. 2022 Sep 23;13(10):1556-1557.