Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Ceefourin-1
Catalog No.: PC-20572Not For Human Use, Lab Use Only.
Ceefourin-1 is a highly selective inhibitor of multidrug resistance protein 4 (MRP4/ABCC4), inhibits the efflux of a broad range of MRP4 substrates.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Ceefourin-1 is a highly selective inhibitor of multidrug resistance protein 4 (MRP4/ABCC4), inhibits the efflux of a broad range of MRP4 substrates.
Ceefourin-1 potentiates global cytosolic cAMP accumulation in BE(2)-C neuroblastoma cells following forskolin stimulation.
Ceefourin-1 is relatively non-toxic and well tolerated across a broad range of cell lines with IC50 values typically >50 μM.
Ceefourin-1 reverses 6-MP resistance conferred by MRP4 in HEK293-MRP4 cells, and Ceefourin-1 is more potent than MK-571.
Ceefourin-1 exhibits no activity against cell lines overexpressing P-gp (HEK293-Pgp), ABCG2 (HEK293-ABCG2), and MRP1 (MCF7-VP16).
| M.Wt | 294.41 | |
| Formula | C11H10N4S3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Cheung L, et al. Biochem Pharmacol. 2014 Sep 1;91(1):97-108.
2. Jördens MS, et al. Glia. 2015 Nov;63(11):2092-2105.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
