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Chemical Structure : ChemR23 inhibitor 14f
Catalog No.: PC-72833Not For Human Use, Lab Use Only.
ChemR23 inhibitor 14f is a potent and orally active inhibitor of ChemR23 (IC80=12 nM), a G protein-coupled receptor (GPCR) expressed on the surface of plasmacytoid dendritic cells (pDCs).
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ChemR23 inhibitor 14f is a potent and orally active inhibitor of ChemR23 (IC80=12 nM), a G protein-coupled receptor (GPCR) expressed on the surface of plasmacytoid dendritic cells (pDCs).
ChemR23 inhibitor 14f inhibits ChemR23 signaling through receptor internalization.
Oral administration of ChemR23 inhibitor 14f at 30 mg/kg to cynomolgus monkeys demonstrated a sustained pharmacological effect of ChemR23 internalization on pDCs.
| M.Wt | 619.755 | |
| Formula | C31H33N5O5S2 | |
| Appearance | Solid | |
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1. Takamichi Imaizumi, et al. Bioorg Med Chem. 2022 Feb 15;56:116587.
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