Chemical Structure : Claudin 5 binder CL5B
CAS No.:
541529-64-0
Claudin 5 binder CL5B
(CLDN5 binder)
Catalog No.: PC-25817Not For Human Use, Lab Use Only.
Claudin 5 binder CL5B is a small molecule binder of Claudin 5 (CLDN5), binds directly to hCLDN5 with KD of 31.7 uM, opens the blood-brain barrier and safely enhances brain drug delivery.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Claudin 5 binder CL5B is a small molecule binder of Claudin 5 (CLDN5), binds directly to hCLDN5 with KD of 31.7 uM, opens the blood-brain barrier and safely enhances brain drug delivery.
CL5B enhances endothelial permeability and promotes small-molecule permeation.
CL5B reversibly enhances endothelial permeability by altering CLDN5 localization.
CL5B regulates mouse BBB and promotes drug delivery to the brain.
CL5B-mediated methylscopolamine delivery to the brain alleviates epilepsy in an experimental mouse model.
Physicochemical Properties
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M.Wt
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269.34
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Formula
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C17H19NO2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-N-(4-isopropylphenyl)-3-(5-methylfuran-2-yl)acrylamide
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References
1. Inoue S, et al. J Control Release. 2025 Oct 11:114314.
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