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Chemical Structure : ClpP agonist TR-27
Catalog No.: PC-49801Not For Human Use, Lab Use Only.
ClpP agonist TR-27 is a potent small molecule agonist of mitochondrial ClpP protease with KD value of 23.7 nM.
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ClpP agonist TR-27 is a potent small molecule agonist of mitochondrial ClpP protease with KD value of 23.7 nM.
TR-27 exhibits the growth inhibition with a ClpP-dependent manner in both MDA-MB-231 and HEK293 T-REx cells with IC50 of 90.7 and 46.1 nM, respectively.
TR-27 exhibits 20-fold improvement in growth inhibition over the parent molecule ONC201.
TR-27 induces ClpP-dependent proteolysis on the N-terminome of the proteome in MDA-MB-231 cells.
| M.Wt | 430.94 | |
| Formula | C25H23ClN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mark F Mabanglo, et al. Structure. 2023 Feb 2;31(2):185-200.e10.
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