Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Cofilin inhibitor SZ-3
CAS No.: 2556443-73-1
Catalog No.: PC-38009Not For Human Use, Lab Use Only.
Cofilin inhibitor SZ-3 (SZ-3) is a first-in-class small-molecule inhibitor of cofilin, shows potent anti-inflammatory activities.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $348 | In stock | |
| 10 mg | $548 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Cofilin inhibitor SZ-3 (SZ-3) is a first-in-class small-molecule inhibitor of cofilin, shows potent anti-inflammatory activities.
SZ-3 shows no effect on neuronal/microglial survival but prevents microglia from LPS-induced inflammation by decreasing NO and preventing neurotoxicity.
SZ-3 decreases cofilin severing activity, and attenuates microglial activation and suppresses migration and proliferation in LPS-activated HMC-3 cells.
SZ-3 shows significantly decreased NO and TNF-α, significantly increases protein expression of phosphocofilin, and decreases PAR-1 in model for hemorrhagic stroke.
SZ-3-treated SHSY-5Y showed a significant increase in cell viability by significantly reducing nuclear factor-κ B (NF-κB), caspase-3, and high-temperature requirement (HtrA2).
| M.Wt | 481.681 | |
| Formula | C29H43N3O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-(4-(bis(5-(tert-butyl)-2-hydroxybenzyl)amino)cyclohexyl)urea |
|
1. Alaqel SI, et al. ACS Chem Neurosci. 2022 Apr 6;13(7):1014-1029.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
