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Colchicine

Chemical Structure : Colchicine

CAS No.: 64-86-8

Colchicine

Catalog No.: PC-27335Not For Human Use, Lab Use Only.

Colchicine is an orally active alkaloid and potent tubulin inhibitor and a microtubule disrupting agent, inhibits microtubule polymerization with IC50 of 3 nM, also is a competitive antagonist of the α3 glycine receptors (GlyRs).

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Biological Activity

Colchicine is an orally active alkaloid and potent tubulin inhibitor and a microtubule disrupting agent, inhibits microtubule polymerization with IC50 of 3 nM, also is a competitive antagonist of the α3 glycine receptors (GlyRs).

Physicochemical Properties

M.Wt 399.44
Formula C22H25NO6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide

References

1. Bonfoco E, et al. Exp Cell Res. 1995 May;218(1):189-200.

2. Otani K, et al. Sci Rep. 2016 Sep 2;6:32587.

3. Carola Muñoz-Montesino, et al. Front Pharmacol. 2020 Jul 30;11:1143.

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