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Chemical Structure : Compound-326
CAS No.: 1236767-85-3
Catalog No.: PC-63355Not For Human Use, Lab Use Only.
Compound-326 (D5D inhibitor 326, D5D-IN-326) is apotent, selective, orally active delta-5 desaturase (D5D, FADS1/Fatty Acid Desaturase 1) with IC50 of 72 and 22 nM for rat and human D5D, respectively.
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|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $548 | In stock | |
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| 100 mg | Get quote |
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Compound-326 (D5D inhibitor 326, D5D-IN-326) is apotent, selective, orally active delta-5 desaturase (D5D, FADS1/Fatty Acid Desaturase 1) with IC50 of 72 and 22 nM for rat and human D5D, respectively.
Compound-326 shows no inhibition for both rat and human D6D and D9D activity.
Compound-326 lowers insulin resistance and caused body weight loss without significant impact on cumulative calorie intake in high-fat diet-induced obese (DIO) mouse model.
| M.Wt | 473.279 | |
| Formula | C17H11F8N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(2,2,3,3,3-Pentafluoropropoxy)-3-[4-(2,2,2-trifluoroethoxy) phenyl]-5,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-4,6-dione |
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1. Yashiro H, et al. PLoS One. 2016 Nov 10;11(11):e0166198.
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