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Chemical Structure : Compound 3-110-22
Catalog No.: PC-35283Not For Human Use, Lab Use Only.
Compound 3-110-22 is a small molecule that inhibits dengue virus (DENV) by binding to its envelope protein E.
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Compound 3-110-22 is a small molecule that inhibits dengue virus (DENV) by binding to its envelope protein E; inhibits ZIKV PF13-251013-18 with IC90 of 4.0 uM, interacts with recombinant, soluble ZIKV E (ZIKV sE) in biolayer interferometry experiments with a KD of 2.1 uM; inhibits other flavivirus pathogens, inhibits DENV fusion by targeting E; also inhibits West Nile reporter virus with IC50 of 2.9 uM.
| M.Wt | 357.292 | |
| Formula | C18H10F3N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. de Wispelaere M, et al. Cell Chem Biol. 2018 Jun 1. pii: S2451-9456(18)30182-X.
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