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Chemical Structure : Compound 4210
Catalog No.: PC-72669Not For Human Use, Lab Use Only.
Compound 4210 (MyD88 inhibitor 4210) is a small molecule inhibitor of MyD88, inhibits LPS-induced MyD88-mediated NF-kB-dependent expression of reporter activity with IC50 of 10-30 uM.
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Compound 4210 (MyD88 inhibitor 4210) is a small molecule inhibitor of MyD88, inhibits LPS-induced MyD88-mediated NF-kB-dependent expression of reporter activity with IC50 of 10-30 uM.
Compound 4210 4210 inhibited MyD88 dimer formation which is critical for pro-inflammatory signaling.
Compound 4210 inhibited inflammatory cytokine production in human primary cells and increased therapeutic efficacy in mice with exposure to toxins of both grampositive and gram-negative pathogens.
Compound 4210 exhibits broad spectrum antiviral activity by up regulation of type I interferon.
| M.Wt | 713.020 | |
| Formula | C44H64N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shahabuddin Alam, et al. Chem Biol Drug Des. 2015 Aug;86(2):200-9.
2. Kamal U Saikh, et al. Antiviral Res. 2020 Sep;181:104854.
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