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Chemical Structure : Cotransin CT8
Catalog No.: PC-21747Not For Human Use, Lab Use Only.
Cotransin CT8 (CT-08) is a substrate-selective co-translational translocation inhibitor, binds the Sec61 translocon to inhibit cotranslational translocation of a subset of secreted and type I transmembrane proteins.
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Cotransin CT8 (CT-08) is a substrate-selective co-translational translocation inhibitor, binds the Sec61 translocon to inhibit cotranslational translocation of a subset of secreted and type I transmembrane proteins.
Cotransin CT8 (CT-08) inhibits DENV replication in primary human monocyte-derived dendritic cells.
Cotransin CT8 (CT-08) inhibit secretory and transmembrane protein expression.
Cotransin CT8 (CT-08) inhibits cotranslational translocation of TNFα, a type II transmembrane protein that lacks a cleavable signal sequence.
Cotransin CT8 (CT-08) exhibits selectivity for VCAM and TNFα, affecting most of the remaining proteins only at higher concentrations.
| M.Wt | 893.22 | |
| Formula | C50H80N6O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sarah V Maifeld, et al. Chem Biol. 2011 Sep 23;18(9):1082-8.
2. Priya S Shah, et al. Cell. 2018 Dec 13;175(7):1931-1945.e18.
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