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Chemical Structure : Creatine kinase inhibitor CKi-1
Catalog No.: PC-20154Not For Human Use, Lab Use Only.
Creatine kinase inhibitor CKi-1 is a selective, covalent inhibitor of creatine kinases (CKs), inhibits recombinant creatine kinase B (CKB) phosphotransfer activity with IC50 of 1.2 uM, depletes creatine phosphagen energetics in cells.
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Creatine kinase inhibitor CKi-1 is a selective, covalent inhibitor of creatine kinases (CKs), inhibits recombinant creatine kinase B (CKB) phosphotransfer activity with IC50 of 1.2 uM, depletes creatine phosphagen energetics in cells.
Creatine kinase inhibitor CKi-1 (10-20 uM) rapidly and selectively depletes creatine phosphate, and drives toxicity selectively in CK-dependent acute myeloid leukemia.
CKi-1 selectively engages the active site cysteine (Cys283) of CKs in cells.
CKi-1 inhibits cell viability in UCSD-AML1 cells with EC50 of 3.0 uM.
| M.Wt | 254.67 | |
| Formula | C11H11ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Narek Darabedian, et al. Nat Chem Biol. 2023 Feb 23. doi: 10.1038/s41589-023-01273-x.
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