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Chemical Structure : Crenolanib
CAS No.: 670220-88-9
Catalog No.: PC-43403Not For Human Use, Lab Use Only.
Crenolanib (CP-868596) is a potent, selective PDGFR/Flt-3 inhibitor with Ki of 3.2, 2.1 and 0.74 nM for wild-type PDGFRα, PDGFRβ and FLT3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $148 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Crenolanib (CP-868596) is a potent, selective PDGFR/Flt-3 inhibitor with Ki of 3.2, 2.1 and 0.74 nM for wild-type PDGFRα, PDGFRβ and FLT3, respectively.
Crenolanib (CP-868596) displays >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src.
Crenolanib (CP-868596) also is a potent inhibitor of PDGFRα D842V-mutant kinase with IC50 of 10 nM, significantly more potent than imatinib in inhibiting the kinase activity of imatinib-resistant PDGFRA kinases (D842I, D842V, D842Y, DI842-843IM, and deletion I843).
Crenolanib is active against models of drug-resistant FLT3-ITD-positive AML.
| M.Wt | 443.5408 | |
| Formula | C26H29N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Piperidinamine, 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]- |
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2. Zimmerman EI, et al. Blood. 2013 Nov 21;122(22):3607-15.
3. Galanis A, et al. Blood. 2014 Jan 2;123(1):94-100.
4. Smith CC, et al. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5319-24.
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