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Chemical Structure : Cyclocreatine Phosphate
Catalog No.: PC-61918Not For Human Use, Lab Use Only.
Cyclocreatine Phosphate (AM 285) is an analog of the creatine kinase CKMT1 substrate creatine and inhibitor of the creatine biosynthesis pathway.
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Cyclocreatine Phosphate (AM 285) is an analog of the creatine kinase CKMT1 substrate creatine and inhibitor of the creatine biosynthesis pathway; decreases intracellular ATP level, suppresses arginine-creatine metabolism, selectively decreases the viability, promotes cell cycle arrest and apoptosis of human EVI1-positive AML cells; prolongs survival in human orthotopic and mouse primary AML models.
| M.Wt | 287.3 | |
| Formula | C4H8N3O5P • 2K | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Woznicki DT, et al. J Neurochem. 1988 May;50(5):1640-7.
2. Turner DM, et al. J Biol Chem. 1987 May 15;262(14):6605-9.
3. Griffiths GR, et al. J Biol Chem. 1976 Apr 10;251(7):2049-54.
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