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D211

Chemical Structure : D211

CAS No.: 1971075-99-6

D211 ((S,S)-D211, D-211)

Catalog No.: PC-60140Not For Human Use, Lab Use Only.

D211 is a potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs), displays picomolar potency against AML cancer cell lines.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    D211 is a potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs), displays picomolar potency against AML cancer cell lines.

    Physicochemical Properties

    M.Wt 656.739
    Formula C39H36N4O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (6aS,6a'S)-3,3'-(propane-1,3-diylbis(oxy))bis(2-methoxy-7,12-dihydrobenzo[5,6][1,4]diazepino[1,2-b]isoquinolin-14(6aH)-one)

    References

    1. Sean W. Smith, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00436

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