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D211

Chemical Structure D211

CAS No.: 1971075-99-6

D211 ((S,S)-D211;D-211)

Catalog No.: PC-60140Not For Human Use, Lab Use Only.

A novel potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A novel potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs); displays picomolar potency against AML cancer cell lines.

Physicochemical Properties

M.Wt 656.739
Formula C39H36N4O6
CAS No. 1971075-99-6
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name

(6aS,6a'S)-3,3'-(propane-1,3-diylbis(oxy))bis(2-methoxy-7,12-dihydrobenzo[5,6][1,4]diazepino[1,2-b]isoquinolin-14(6aH)-one)

Clinical Information

References

1. Sean W. Smith, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00436

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