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Chemical Structure : DA-0218
Catalog No.: PC-72205Not For Human Use, Lab Use Only.
DA-0218 (DA0218) is a novel potent, selective Nav1.7 inhibitor, inhibits sodium currents in Nav1.7-expressing human embryonic kidney 293 cells with IC50 of 0.74 uM.
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DA-0218 (DA0218) is a novel potent, selective Nav1.7 inhibitor, inhibits sodium currents in Nav1.7-expressing human embryonic kidney 293 cells with IC50 of 0.74 uM.
DA-0218 has no effect on sodium currents in Nav1.5-transfected human embryonic kidney 293 cells in patch-clamp experiments.
DA-0218 shows analgesic activity predominantly in phase II in formalin-induced inflammatory pain mouse model.
DA-0218 produced acute reduction in paclitaxel-induced mechanical allodynia, and inhibited histamine-induced acute itch and lymphoma-induced chronic itch.
| M.Wt | 543.711 | |
| Formula | C36H37N3O2 | |
| Appearance | Solid | |
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1. Sharat Chandra, et al. Anesthesiology. 2020 Sep;133(3):611-627.
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