DC-BPi-11 hydrochloride

Chemical Structure : DC-BPi-11 hydrochloride

Catalog No.: PC-28097Not For Human Use, Lab Use Only.

DC-BPi-11 hydrochloride is a potent, high affinity, selective BPTF bromodomain inhibitor with IC50 of 26.9 nM in HTRF assays and SPR KD of 20.7 nM, shows >100-fold selectivity over other BRD targets.

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Biological Activity

DC-BPi-11 hydrochloride is a potent, high affinity, selective BPTF bromodomain inhibitor with IC50 of 26.9 nM in HTRF assays and SPR KD of 20.7 nM, shows >100-fold selectivity over other BRD targets.

Physicochemical Properties

M.Wt	433.96
Formula	C20H24ClN5O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N-Dimethyl-3-(5-(2-(methylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-indol-1-yl)propan-1-amine hydrochloride

References

1. Lu T, et al. J Med Chem. 2021 Aug 26;64(16):12075-12088.

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