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Chemical Structure : DC-SX029
Catalog No.: PC-72765Not For Human Use, Lab Use Only.
DC-SX029 is a new small-molecule sorting nexin 10 (SNX10) inhibitor (KD=0.935 uM), blocks the SNX10-PIKfyve interaction, decreases TBK1/c-Rel signaling activation.
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DC-SX029 is a new small-molecule sorting nexin 10 (SNX10) inhibitor (KD=0.935 uM), blocks the SNX10-PIKfyve interaction, decreases TBK1/c-Rel signaling activation.
DC-SX029 reduced inflammatory response by inhibiting PIKfyve-mediated TBK1/c-Rel signal activation in BMDMs, inhibited mRNA levels of proinflammatory cytokines IL12/23 with IC50 of 18.6 uM.
DC-SX029 alleviated DSS-induced mouse colitis, improved IL-10-deficient mouse colitis.
| M.Wt | 398.353 | |
| Formula | C14H17F3N2O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Weilian Bao, et al. Pharmacol Res. 2021 Jul;169:105679.
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