DC-U43-10 | USP8 inhibitor | Probechem Biochemicals

Chemical Structure : DC-U43-10

CAS No.: 2477650-96-5

DC-U43-10 (USP8-IN-1)

Catalog No.: PC-26962Not For Human Use, Lab Use Only.

DC-U43-10 is a specific small molecule USP8 inhibitor with IC50 of 2.6 uM, exhibits 10-fold selectivity against USP7.

Packing	Price	Stock
5 mg	$158	In stock
10 mg	$248	In stock
25 mg	$398	In stock
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Biological Activity

DC-U43-10 is a specific small molecule USP8 inhibitor with IC50 of 2.6 uM, exhibits 10-fold selectivity against USP7.
DC-U43-10 has KD of 10.5 uM in surface plasmon resonance (SPR) assays.
DC-U43-10 inhibits the colony formation of H1975 cells with EC50 of 30.8 uM.

Physicochemical Properties

M.Wt	387.46
Formula	C18H21N5O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-amino-4-methoxyphenyl)-N-(4-nitrophenyl)piperazine-1-carbothioamide

References

1. Jie Han, et al. Bioorg Chem. 2020 Aug:101:103962.

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DC-U43-10 (USP8-IN-1)

Biological Activity

Physicochemical Properties

References

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