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Chemical Structure : DC541
Catalog No.: PC-38209Not For Human Use, Lab Use Only.
DC541 (DC 541) is a potent, selective peptidomimetic inhibitor of Protein N-terminal methyltransferase NTMT1 with IC50 of 0.34 uM.
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DC541 (DC 541) is a potent, selective peptidomimetic inhibitor of Protein N-terminal methyltransferase NTMT1 with IC50 of 0.34 uM.
DC541 exhibits over 300-fold selectivity to several methyltransferases.
DC541 inhibited funtions the cellular α-N-terminal methylation level of regulator of chromosome condensation 1 (RCC1, IC50 value of 30 μM) in human colorectal cancer HT29 cells.
| M.Wt | 529.641 | |
| Formula | C30H35N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dongxing Chen, et al. ACS Med Chem Lett. 2021 Mar 1;12(3):485-493.
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