DCLK1 inhibitor a24

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Chemical Structure : DCLK1 inhibitor a24

Catalog No.: PC-24446Not For Human Use, Lab Use Only.

DCLK1 inhibitor a24 is an effective inhibitor of doublecortin-like kinase 1 (DCLK1) with IC50 of 179.7 nM, KD of 2.12 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DCLK1 inhibitor a24 is an effective inhibitor of doublecortin-like kinase 1 (DCLK1) with IC50 of 179.7 nM, KD of 2.12 uM.
a24 effectively inhibited lipopolysaccharide (LPS)-induced inflammation via inhibiting DCLK1-mediated IKKβ phosphorylation.
a24 exhibited stronger anti-inflammatory activity than NVP-TAE684.
a24 showed in vivo anti-inflammatory activity in an LPS-challenged acute lung injury model.

Physicochemical Properties

M.Wt	590.16
Formula	C26H32ClN7O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-4-methylpiperazine-1-carbothioamide

References

1. Cai B, et al. Bioorg Chem. 2024 Apr;145:107215.

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