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Chemical Structure : DC_AC50
Catalog No.: PC-61245Not For Human Use, Lab Use Only.
DC_AC50 (DCAC50) is a small molecule that inhibits the human copper chaperones Atox1 and CCS (Kd=6.8 and 8.2 uM), blocks copper trafficking and significantly attenuates cancer cell proliferation.
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DC_AC50 (DCAC50) is a small molecule that inhibits the human copper chaperones Atox1 and CCS (Kd=6.8 and 8.2 uM), blocks copper trafficking and significantly attenuates cancer cell proliferation; induces cellular reactive oxygen species (ROS) accumulation and reduces cellular ATP production, induces mitochondria defects and decreases lipid biosynthesis through AMPK activation; suppresses tumour growth effectively without affecting normal tissues in mice.
| M.Wt | 424.264 | |
| Formula | C17H12BrF2N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang J, et al. Nat Chem. 2015 Dec;7(12):968-79.
2. Karginova O, et al. Mol Cancer Ther. 2019 Mar 1. pii: molcanther.0667.2018.
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