Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : DDC-03-024-01
Catalog No.: PC-73295Not For Human Use, Lab Use Only.
DDC-03-024-01 is a potent, mutant-selective allosteric inhibitor of EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) mutants with IC50 of 10 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
DDC-03-024-01 is a potent, mutant-selective allosteric inhibitor of EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) mutants with IC50 of 10 nM.
DDC-03-024-01 displays no significant activity aginst WT EGFR (IC50>1000 nM) and high selectivity by kinome profiling.
Cotreatment with cetuximab resulted in antiproliferative activity in EGFR mutant Ba/F3 cells (IC50=0.36 uM, L858R/T790M).
| M.Wt | 508.597 | |
| Formula | C31H29FN4O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Dries J H De Clercq, et al. ACS Med Chem Lett. 2019 Oct 22;10(11):1549-1553.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
