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Chemical Structure : DDD85646
CAS No.: 1215010-55-1
Catalog No.: PC-62880Not For Human Use, Lab Use Only.
DDD 85646 is a potent, specific, dual N-Myristoyltransferase NMT1/NMT2 inhibitor with IC50 of 17 nM/22 nM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 25 mg | $548 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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DDD 85646 (IMP-366) is a potent, specific, dual N-Myristoyltransferase NMT1/NMT2 inhibitor with IC50 of 17 nM/22 nM respectively.
DDD 85646 (IMP-366) inhibits myristoylation of an overexpressed protein construct in-cell-based microscopy assays.
DDD 85646 (IMP-366) has no significant affect protein synthesis in cells.
DDD 85646 (IMP-366) causes complete inhibition of N-myristoylation in cells at 1-10 uM.
DDD 85646 (IMP-366) induces ER-stress, cell cycle arrest, and apoptosis in cancer cells.
| M.Wt | 495.423 | |
| Formula | 21H24Cl2N6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,6-dichloro-4-(2-(piperazin-1-yl)pyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide |
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1. Thinon E, et al. Nat Commun. 2014 Sep 26;5:4919.
2. Thinon E, et al. ACS Chem Biol. 2016 Aug 19;11(8):2165-76.
3. Brand S, et al. J Med Chem. 2012 Jan 12;55(1):140-52.
4. Wouter W. Kallemeijn, et al. Cell Chem Biol. 2019 Jun 20; 26(6): 892–900.e4.
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