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DDL-218

Chemical Structure : DDL-218

CAS No.: 2767324-34-3

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DDL-218 (DDL218)

Catalog No.: PC-24533Not For Human Use, Lab Use Only.

DDL-218 is an orally brain-permeable small-molecule sirtuin 1 (SirT1) enhancer, increases SirT1 protein levels in ApoE4-expressing N2a (N2a-E4) murine neuroblastoma cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DDL-218 is an orally brain-permeable small-molecule sirtuin 1 (SirT1) enhancer, increases SirT1 protein levels in ApoE4-expressing N2a (N2a-E4) murine neuroblastoma cells.
DDL-218 induced increases in NFYb, PRMT5, PPP2r5e and SirT1 mRNA levels.
DDL-218 treatment elicited improvement in memory in the AD model.
DDL-218 has potential to modulate neuronal activity that may clinically provide an improvement in cognitive function and complement the current anti-Aβ antibody monotherapy.

Physicochemical Properties

M.Wt 222.29
Formula C12H18N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

L-Alanine, 1,1-dimethyl-2-(4-pyridinyl)ethyl ester

References

1. Campagna J, et al. Sci Rep. 2025 Apr 23;15(1):14028.

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