DDO-4279 | PP5 degrader | Probechem Biochemicals

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Chemical Structure : DDO-4279

DDO-4279 (DDO4279)

Catalog No.: PC-27292Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DDO-4279 is a selective serine/threonine phosphatase PP5 degrader with DC50 of 6.9 uM, selectively degrades PP5 via the ubiquitin-proteasome pathway, thereby downregulating PP5 substrate proteins PPARγ and GR.
DDO-4279 dose-dependently reduced body weight gain in ob/ob mice (outperforming the clinical drug semaglutide).
DDO-4279 ameliorated hepatomegaly and hepatic steatosis, and exhibited no renal toxicity.

Physicochemical Properties

M.Wt	335.78
Formula	C17H18ClNO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,2R,3S,4R)-3-(7-chloro-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid

References

1. Mingxiao Gu, et al. RSC Med Chem. 2026 Jun 30. doi: 10.1039/d6md00191b.

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DDO-4279 (DDO4279)

Biological Activity

Physicochemical Properties

References

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