DIX-01 | IKZF1/3 and GSPT1 degrader | Probechem Biochemicals

Chemical Structure : DIX-01

DIX-01 (DIX01)

Catalog No.: PC-28662Not For Human Use, Lab Use Only.

DIX-01 is a potent dual IKZF1/3 and GSPT1 molecular glue degrader with DC50 values of 19.80 nM for IKZF1, 45.31 nM for IKZF3, and 120.1 nM for GSPT1 in MV4-11 cells.

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Biological Activity

DIX-01 is a potent dual IKZF1/3 and GSPT1 molecular glue degrader with DC50 values of 19.80 nM for IKZF1, 45.31 nM for IKZF3, and 120.1 nM for GSPT1 in MV4-11 cells.
DIX-01 mediates protein degradation through the proteasomal pathway.
DIX-01 does not degrade CK1α.
DIX-01 exhibits potent cytotoxicity in multiple cancer cell lines (22Rv1, MV4-11, HL-60, MOLM13), with IC50 values in the nanomolar range.
DIX-01 significantly inhibits tumor growth in a zebrafish xenograft model transplanted with human acute myeloid leukemia cells (MV4-11).

Physicochemical Properties

M.Wt	538.60
Formula	C31H30N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,6-dioxopiperidin-3-yl)-4-((2-((4-ethyl-5-methyl-5,6-dihydrophenanthridin-9-yl)oxy)ethyl)amino)isoindoline-1,3-dione

References

1. Tang C, et al. Bioorg Chem. 2026 Feb;169:109367.

DIX-01 (DIX01)

Biological Activity

Physicochemical Properties

References

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