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Chemical Structure : DJ-1 inhibitor comp-23
CAS No.: 724737-74-0
Catalog No.: PC-22171Not For Human Use, Lab Use Only.
DJ-1 inhibitor comp-23 is a small molecule binding to DJ-1 (PARK7) with binding constant (Kd) of 0.1 uM, exerts a neuroprotective effect by reducing ROS-mediated neuronal injury.
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|---|---|---|---|
| 25 mg | $88 | In stock | |
| 50 mg | $138 | In stock | |
| 100 mg | $198 | In stock | |
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DJ-1 inhibitor comp-23 is a small molecule binding to DJ-1 (PARK7) with binding constant (Kd) of 0.1 uM, exerts a neuroprotective effect by reducing ROS-mediated neuronal injury.
Comp-23 prevents oxidative stress-induced death of SH-SY5Y cells and primary neuronal cells of the ventral mesencephalon but not that of DJ-1-knockdown SH-SY5Y cells.
Comp-23 exerts a neuroprotective effect by reducing ROS-mediated neuronal injury Comp-23 inhibited the production of reactive oxygen species (ROS) induced by oxidative stress and preventsexcess oxidation of DJ-1.
Comp-23 prevented dopaminergic cell death in the substantia nigra and restored movement abnormality in 6-hydroxyldopamine-injected and rotenone-treated PD model rats and mice.
Comp-23 also reduces infarct size of cerebral ischemia in rats that had been induced by middle cerebral artery occlusion.
| M.Wt | 417.47 | |
| Formula | C24H23N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3,4,5-trimethoxy-N-(4-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl)benzamide |
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1. Yoshihisa Kitamura, et al. Mol Neurodegener. 2011 Jul 8;6(1):48.
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